Гормон-лекарство

В ближайшее время появится лекарственный препарат, который позволит предотвращать необратимый паралич, наступающий в результате тяжелых травм позвоночника. Это синтетический аналог тиролиберина (ТВГ) — природного гормона, стимулирующего высвобождение тиреотропина. При застарелых травмах позвоночника он, правда, не помогает, но, если его применить своевременно, эффективен при травмах, связанных с пережатием (но не разрывом) спинного мозга.

О перспективности этого препарата для предотвращения паралича можно судить по работам А. Фадена, выполненным в Медицинском центре Калифорнийского университета в Сан-Франциско. Фаден и его коллеги показали, что введение лабораторным животным природного ТВГ или его синтетического аналога (несколько отличающегося химически) в течение первых нескольких часов после травмирования позвоночника препятствует развитию паралича.

Природный ТВГ, который секретируется гипоталамусом, представляет собой пептид, состоящий из трех аминокислот. Функция ТВГ — воздействие на гипофиз, в котором он вызывает секрецию гормона, стимулирующего щитовидную железу, что в свою очередь «включает» в ней синтез определенного набора гормонов.

Еще лет десять назад было установлено, что большинство нарушений, связанных с повреждением позвоночника, не вызываются самой травмой непосредственно, а возникают как следствие реакции организма на повреждение. Сжатие спинного мозга приводит к локальному разрушению серого вещества. При этом окружающее белое вещество может остаться более или менее неповрежденным.

Серое вещество спинного мозга состоит из горизонтально ориентированных нервных клеток и нервных волокон, которые передают сигналы, следующие к периферическим органам и от них. Белое же вещество образовано вертикальными нервными волокнами, которые отвечают за передачу сигналов в головной мозг и обратно.

 

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