Типы вариабельного участка

Гибридная клетка такого типа при своем делении может утрачивать хромосомы человека (но сохраняет полный набор хромосом мыши), поэтому, по мере того как клетки делятся и размножаются, в последующих их поколениях хромосом человека остается все меньше и меньше; много поколений спустя каждая гибридная клетка будет содержать лишь по нескольку хромосом человека.

С целью определить, какие хромосомы содержат гены, кодирующие составные части молекул антител, мы исследовали несколько наборов таких клеток. В любой клетке, синтезирующей часть молекулы иммуноглобулина, наверняка должна иметься одна из необходимых хромосом. Мы установили, какие хромосомы содержат гены каждой из определенных частей молекулы иммуноглобулина, подметив, какие хромосомы человека неизменно присутствуют в клетках, производящих эти части молекулы, и отсутствуют в клетках, в которых они не производятся.

Молекула антитела построена из четырех белковых цепей; цепи объединены в две идентичные пары и образуют молекулу, напоминающую по форме букву Y (см. иллюстрацию на с. 21). Более длинная цепь в паре называется тяжелой (Н) цепью, более короткая — легкой (L) цепью. В каждой цепи различают два участка — вариабельный и константный. Вариабельный участок узнает антиген и связывается с ним; константный участок ответствен за функцию, которую антитело осуществляет уже после того, как оно связалось с антигеном (так называемая эффекторная функция). Существует множество различных типов вариабельного участка, поскольку антитела действуют с высокой степенью избирательности: каждое антитело связывается лишь с одним специфическим антигеном. Число вариантов константного участка невелико: в легких цепях встречаются лишь два его типа (которые обозначают х и X), а в тяжелых цепях — 10 типов. Поэтому антитела против различных антигенов вполне могут выполнять одни и те же функции. Каждая зрелая В-клетка способна образовывать антитела только одного типа, и ее хромосомы содержат последовательности ДНК, кодирующие вариабельные и константные участки, характерные для этих антител .

 

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  116. 「今日は何となしに、自由にしとこうかな?」カナフレックス2chさんをお昼に誘うつもりで連絡を取ったら、最初の一声がこれでした。

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