Окружающая клетки жидкость

Рецепторы связывают частицы ЛНП, извлекая их из окружающей клетки жидкости. Затем ЛНП переходят внутрь клеток и разрушаются там, в результате чего высвобождается холестерол, который клетки используют для своих нужд. Обеспечивая клетки холестеролом, рецепторы одновременно выполняют еще одну важную физиологическую функцию, весьма существенную для предотвращения развития атеросклероза: они удаляют ЛНП из кровяного русла.

Количество рецепторов, экспонированных на клеточной поверхности, варьирует в зависимости от потребности клеток в холестероле. Когда такая потребность невелика, образуется избыток холестерола, и чтобы защитить себя от него, клетки синтезируют меньше рецепторов ЛНП, в результате чего поток ЛНП внутрь клеток ослабляется. Однако эта зашита обходится дорогой ценой: уменьшение числа рецепторов приводит к снижению скорости удаления ЛНП из кровяного русла, концентрация ЛНП в крови повышается и развиваются атеросклеротические явления.

Мы предположили, что высокое содержание ЛНП в крови у многих американцев обусловлено комбинацией факторов, угнетающих образование рецепторов ЛНП.

 

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