Инфекционный агент

Какие есть основания предполагать, что болезнь Альцгеймера инфекционного происхождения, если больные обычно неплохо выглядят и у них никогда не наблюдается таких признаков инфекции мозга, как лихорадочное состояние или присутствие белков и белых кровяных клеток в спинномозговой жидкости? Таких оснований два: скрэпи и болезнь Крейцфельдта—Якоба. Скрэпи — это широко распространенная у овец и коз болезнь мозга, характеризующаяся медленным развитием и неизбежным смертельным исходом. Второе заболевание обычно поражает людей в возрасте от 55 до 75 лет и вызывает прогрессирующее слабоумие, нарушения зрения, осанки и управления движениями; смерть наступает примерно через год после начала болезни. Болезнь Крейцфельдта—Якоба встречается довольно редко: за год обнаруживается всего один новый случай на миллион человек.

Несколько лет назад было установлено, что оба заболевания заразны: их можно передать животным путем инъекции в мозг экстракта пораженной ткани. Это доказывает, что они вызываются инфекционным агентом, возможно, вирусом. Фактор, вызывающий болезнь, можно выделить из мозга и других тканей. До сих пор нет свидетельств того, что при этих заболеваниях имеют место воспаление мозга или же функциональное расстройство какого-либо другого органа. Более того, от момента заражения до первого проявления признаков болезни может пройти очень большой инкубационный период (примерно четверть нормальной для данного организма продолжительности жизни). Предполагалось, что гипотетический инфекционный агент может быть необычным, «медленным» вирусом.

Сейчас имеются данные, позволяющие думать, что возбудители скрэпи и болезни Крейцфельдта—Якоба — это вообще не вирусы, а еще более необычные инфекционные частицы, названные прионами. Такие частицы впервые были выделены из мозга овец, больных скрэпи, С. Прузинером из Медицинской школы Калифорнийского университета в Сан-Франциско*. В отличие от всех других известных инфекционных агентов прионы, вероятно, не содержат ни ДНК, ни РНК, а состоят из одного белка.

 

 

 

112 Comments

  1. 136680 665587Somebody necessarily support to make seriously articles I may possibly state. That will be the very very first time I frequented your internet page and to this point? I surprised with the research you created to make this actual put up amazing. Great task! 781947

  2. 241718 573865Wow, amazing blog layout! How lengthy have you ever been running a blog for? you make running a blog glance effortless. The total look of your internet web site is magnificent, well the content material! 943117

  3. Fantastic beat ! I wish to apprentice whilst you amend
    your web site, how could i subscribe for a weblog website?
    The account helped me a applicable deal. I were a little bit acquainted
    of this your broadcast provided vibrant clear idea

  4. I’m amazed, I must say. Rarely do I come across a blog that’s both educative and
    engaging, and without a doubt, you’ve hit the nail on the
    head. The problem is something which too few folks are speaking intelligently about.
    Now i’m very happy that I stumbled across this during my hunt for something regarding this.

  5. Thank you for any other informative website. Where else may just
    I get that type of information written in such a perfect method?
    I have a mission that I am simply now running on, and I have been on the glance out for such information.

  6. Lona:

    What i don’t understood is actually how you’re
    now not really much more smartly-liked than you might be right now.
    You’re so intelligent. You realize therefore significantly with regards to this
    subject, made me for my part consider it from a lot of various angles.
    Its like women and men are not interested until it is something to do with Girl gaga!
    Your individual stuffs great. Always maintain it up!

  7. Thanks for some other wonderful article. Where else may just anyone
    get that kind of information in such a perfect means of writing?
    I’ve a presentation subsequent week, and I’m on the search for such info.

  8. Your way of telling everything in this article is truly fastidious, every one can easily understand it, Thanks a lot.

  9. Heya i am for the first time here. I found this board and I find It truly useful & it helped
    me out much. I hope to give something back and aid others like you aided me.

  10. Hurrah! At last I got a weblog from where I can in fact obtain valuable facts
    concerning my study and knowledge.

  11. Hi there, just became alert to your blog through Google, and found that it’s truly informative.
    I’m gonna watch out for brussels. I will be grateful if you continue this in future.
    Numerous people will be benefited from your writing.
    Cheers!

  12. I loved as much as you’ll receive carried out right here.
    The sketch is attractive, your authored material stylish.
    nonetheless, you command get bought an edginess over that
    you wish be delivering the following. unwell unquestionably
    come further formerly again as exactly the same nearly very
    often inside case you shield this increase.

  13. I seriously love your blog.. Very nice colors & theme.
    Did you build this site yourself? Please reply back as I’m looking to create my
    own personal blog and want to learn where you got
    this from or just what the theme is called.
    Thank you!

  14. Wow, superb blog layout! How long have you been blogging for?
    you make blogging look easy. The overall look of
    your web site is magnificent, as well as the content!

  15. I do not even understand how I stopped up here, but I believed this publish was great.
    I don’t understand who you’re but definitely you’re going to a
    famous blogger if you are not already. Cheers!

  16. Good way of explaining, and good article to obtain facts about my presentation subject matter,
    which i am going to convey in school.

  17. Yes! Finally something about viable business strategy.

  18. Ryan:

    Hi! I know this is kinda off topic but I’d figured I’d ask.

    Would you be interested in exchanging links or maybe guest authoring
    a blog post or vice-versa? My site discusses a lot of the same subjects
    as yours and I think we could greatly benefit from each other.
    If you are interested feel free to shoot me an email.

    I look forward to hearing from you! Wonderful blog by the way!

  19. Hey, I think your blog might be having browser compatibility issues.
    When I look at your blog in Opera, it looks fine but when opening
    in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up!
    Other then that, superb blog!

  20. Wow, incredible blog structure! How lengthy have you been blogging for?
    you made blogging look easy. The overall look of your website is excellent, let alone
    the content material!

  21. Right away I am going to do my breakfast, once having my breakfast coming again to read more news.

  22. Hello there, I discovered your blog by means
    of Google whilst searching for a similar matter, your web site got
    here up, it seems to be great. I’ve bookmarked it in my google bookmarks.

    Hi there, just become alert to your blog through Google,
    and located that it’s truly informative. I am going to be careful for brussels.
    I will be grateful in the event you continue this in future.

    Lots of folks will be benefited out of your writing.
    Cheers!

  23. Hi there just wanted to give you a quick heads up.
    The words in your article seem to be running off the screen in Firefox.

    I’m not sure if this is a format issue or something to do
    with web browser compatibility but I thought I’d post to
    let you know. The design look great though! Hope you get the problem resolved
    soon. Many thanks

  24. Link exchange is nothing else however it is only placing the other person’s web site
    link on your page at proper place and other person will also do similar for you.

  25. Hmm it looks like your blog ate my first comment (it was extremely long) so I guess I’ll just sum it up what I wrote and say,
    I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger but
    I’m still new to the whole thing. Do you have any tips
    and hints for beginner blog writers? I’d really appreciate it.

  26. Incredible points. Solid arguments. Keep up the amazing work.

  27. I know this if off topic but I’m looking into starting my own blog and was wondering what all is
    required to get setup? I’m assuming having
    a blog like yours would cost a pretty penny? I’m not very internet savvy so I’m not 100% positive.
    Any suggestions or advice would be greatly appreciated.
    Many thanks

  28. I am regular reader, how are you everybody? This article posted at this website is really pleasant.

  29. Thanks for your marvelous posting! I definitely enjoyed reading it, you are a great author.I will make sure to bookmark your blog and will eventually come back someday.
    I want to encourage continue your great writing, have a nice afternoon!

  30. Hi there mates, how is all, and what you would like to say regarding this piece
    of writing, in my view its truly awesome designed for me.

  31. Hi there! I know this is somewhat off topic but I was wondering if you knew where I
    could find a captcha plugin for my comment form?
    I’m using the same blog platform as yours and I’m having difficulty finding one?
    Thanks a lot!

  32. Appreciating the commitment you put into your blog and in depth information you offer.
    It’s nice to come across a blog every once in a while that isn’t the
    same outdated rehashed material. Great read!
    I’ve bookmarked your site and I’m adding your RSS feeds to my Google account.

  33. Hello there, I found your website via Google while
    searching for a related matter, your site came up,
    it appears to be like good. I’ve bookmarked it
    in my google bookmarks.
    Hello there, just became aware of your weblog via Google,
    and found that it’s really informative. I’m going to watch out for brussels.
    I’ll appreciate when you proceed this in future.
    A lot of people might be benefited out of your writing. Cheers!

  34. Erna:

    Fantastic website. Lots of helpful info here. I am sending
    it to a few pals ans also sharing in delicious. And certainly, thanks for your effort!

  35. Good day! Do you know if they make any plugins to
    safeguard against hackers? I’m kinda paranoid about losing everything I’ve
    worked hard on. Any tips?

  36. We are a group of volunteers and opening a new scheme in our community.

    Your website offered us with valuable information to work on. You have
    done a formidable job and our entire community will be grateful to you.

  37. Great blog you have here but I was curious if you knew of any discussion boards that cover
    the same topics talked about here? I’d really like
    to be a part of online community where I can get feed-back from other experienced people that share the same interest.

    If you have any suggestions, please let me know. Kudos!

  38. What’s up, yup this post is genuinely nice and I have learned lot of things from it concerning blogging.
    thanks.

  39. I will immediately grasp your rss as I can’t find your email subscription link or e-newsletter service.
    Do you’ve any? Please allow me understand in order that I may subscribe.
    Thanks.

  40. Greate article. Keep writing such kind of info on your blog.
    Im really impressed by it.
    Hello there, You’ve performed an excellent job. I will definitely digg it and for my part suggest to my friends.

    I am sure they will be benefited from this web site.

  41. whoah this weblog is excellent i love reading your articles.
    Stay up the great work! You realize, lots of individuals are looking around for this information, you can aid them greatly.

  42. I am extremely inspired together with your writing talents as smartly as with the structure for your
    weblog. Is that this a paid theme or did you customize it yourself?

    Either way stay up the nice high quality writing, it’s uncommon to look a
    nice weblog like this one nowadays..

  43. Yes! Finally someone writes about apple chief operating.

  44. Fine way of explaining, and good post to get facts regarding my
    presentation topic, which i am going to present in school.

  45. My relatives always say that I am wasting my time here
    at net, except I know I am getting knowledge every day
    by reading such pleasant articles or reviews.

  46. Hello colleagues, its great post concerning teachingand entirely
    defined, keep it up all the time.

  47. Aw, this was a very nice post. Taking the time and actual effort to create a very good article… but what can I say… I procrastinate a whole lot and never
    manage to get nearly anything done.

  48. I don’t even know the way I ended up right here, but I
    thought this put up was great. I do not know who you might be however
    definitely you’re going to a famous blogger should you are not already.
    Cheers!

  49. Thanks to my father who stated to me concerning this weblog, this weblog
    is actually amazing.

  50. You have made some really good points there. I looked on the net for more info
    about the issue and found most individuals will go along with your views on this site.

  51. I just want to tell you that I’m beginner to blogging and absolutely loved this web-site. Likely I’m planning to bookmark your website . You absolutely come with superb posts. Many thanks for sharing your website.

  52. I love your blog.. very nice colors & theme. Did you design this website yourself or did you hire someone
    to do it for you? Plz respond as I’m looking to construct my own blog
    and would like to find out where u got this from. cheers

  53. Hi there! This is kind of off topic but I need some
    guidance from an established blog. Is it difficult to set up your own blog?
    I’m not very techincal but I can figure things out pretty fast.
    I’m thinking about creating my own but I’m
    not sure where to begin. Do you have any tips or suggestions?
    Thanks

  54. I could not resist commenting. Well written!

  55. As a Newbie, I am permanently browsing online for articles that can help me. Thank you

  56. You could definitely see your skills within the work you write.
    The sector hopes for even more passionate writers such as you who are not afraid
    to mention how they believe. At all times follow your heart.

  57. Can I simply just say what a relief to uncover somebody who really
    knows what they are talking about online. You certainly understand
    how to bring an issue to light and make it important. A lot more people need to look at this
    and understand this side of the story. It’s surprising you are not more popular
    because you certainly possess the gift.

  58. I pay a visit each day a few web sites and websites to read articles, but this webpage presents feature based articles.

  59. Howdy! This is my 1st comment here so I just wanted to give a quick
    shout out and tell you I genuinely enjoy reading
    through your blog posts. Can you recommend any other blogs/websites/forums that
    go over the same subjects? Thanks!

  60. I’m no longer sure the place you are getting your information,
    however great topic. I must spend some time finding out more
    or working out more. Thanks for great info I used to be searching for this info for my mission.

  61. wonderful post, very informative. I wonder why the other experts of this sector don’t notice this. You must continue your writing. I am confident, you’ve a great readers’ base already!

  62. fantastic post, very informative. I’m wondering why the opposite specialists of this sector
    don’t notice this. You should proceed your writing. I am sure, you’ve a huge readers’ base already!

  63. You’re so interesting! I do not believe I have read a single
    thing like this before. So good to discover
    somebody with a few original thoughts on this subject matter.

    Seriously.. many thanks for starting this up. This website is one thing that is required
    on the web, someone with a little originality!

  64. Its such as you learn my thoughts! You appear to grasp a lot about this,
    like you wrote the book in it or something.

    I think that you can do with some % to power the message home a little bit,
    but instead of that, this is excellent blog. A
    fantastic read. I will definitely be back.

  65. I have been surfing online more than three hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my opinion, if all web owners and bloggers made good content as you did, the internet will be much more useful than ever before.

  66. certainly like your web-site but you have to check the spelling on several of your posts. A number of them are rife with spelling issues and I in finding it very troublesome to tell the reality however I will surely come back again.

  67. Hello, you used to write great, but the last several posts have been kinda boring¡K I miss your super writings. Past several posts are just a little out of track! come on!

  68. Hello, Neat post. There is an issue with
    your web site in internet explorer, may test this? IE nonetheless is the market leader and a large element of folks will pass over your wonderful writing because of this problem.

  69. Nice post. I was checking continuously this blog and I am impressed!

    Extremely useful info specially the last part :) I care for such info a lot.
    I was seeking this certain info for a long time.
    Thank you and best of luck.

  70. Hi, Neat post. There is a problem along with your site in web explorer, might check this… IE still is the marketplace chief and a large component of other folks will pass over your magnificent writing because of this problem.

  71. Wonderful, what a blog it is! This blog presents valuable facts to us, keep it up.

  72. I was just searching for this info for some time. After six hours of continuous Googleing, finally I got it in your web site. I wonder what is the lack of Google strategy that don’t rank this kind of informative web sites in top of the list. Normally the top sites are full of garbage.

  73. Wow, fantastic blog layout! How long have you been blogging for? you made blogging look easy. The overall look of your website is fantastic, let alone the content!

  74. Hello, of course this post is genuinely nice and I have learned
    lot of things from it concerning blogging. thanks.

  75. Very interesting subject, appreciate it for posting.

  76. Very nice post. I just stumbled upon your blog and wished to say that I have truly enjoyed browsing your blog posts. In any case I’ll be subscribing to your rss feed and I hope you write again very soon!

  77. Hiya, I’m really glad I have found this information. Today bloggers publish just about gossips and internet and this is really frustrating. A good blog with exciting content, that’s what I need. Thanks for keeping this web site, I’ll be visiting it. Do you do newsletters? Can not find it.

  78. You actually make it seem so easy with your presentation but I find this topic to be really something which I think I would never understand. It seems too complex and very broad for me. I’m looking forward for your next post, I will try to get the hang of it!

  79. I have been browsing on-line greater than three hours lately, yet I by no means discovered any interesting article like yours. It¡¦s beautiful worth enough for me. Personally, if all site owners and bloggers made good content as you probably did, the web shall be much more helpful than ever before.

  80. Wonderful goods from you, man. I have understand your stuff previous to and you’re just extremely great. I actually like what you’ve acquired here, certainly like what you are stating and the way in which you say it. You make it entertaining and you still care for to keep it wise. I can not wait to read far more from you. This is actually a wonderful web site.

  81. I am continually invstigating online for ideas that can benefit me. Thank you!

  82. Hi, Neat post. There’s an issue along with your website in web explorer, might check this… IE still is the marketplace leader and a good component to people will pass over your wonderful writing due to this problem.

  83. Hey There. I found your blog using msn. This is an extremely well written article. I will be sure to bookmark it and return to read more of your useful info. Thanks for the post. I’ll definitely return.

  84. Hello. remarkable job. I did not imagine this. This is a impressive story. Thanks!

  85. I like this site very much, Its a very nice situation to read and get info . «Reason is not measured by size or height, but by principle.» by Epictetus.

  86. Faytech North America is a touch screen Manufacturer of both monitors and pcs. They specialize in the design, development, manufacturing and marketing of Capacitive touch screen, Resistive touch screen, Industrial touch screen, IP65 touch screen, touchscreen monitors and integrated touchscreen PCs. Contact them at http://www.faytech.us, 121 Varick Street,3rd Floor,New York, NY 10013,+1 646 205 3214

  87. I do believe all of the ideas you’ve offered on your post. They’re really convincing and can definitely work. Nonetheless, the posts are too brief for starters. May you please prolong them a little from next time? Thank you for the post.

  88. wonderful points altogether, you simply received a new reader. What may you suggest about your put up that you just made a few days in the past? Any sure?

  89. Hello there! I simply wish to offer you a huge thumbs
    up for your excellent info you have right here on this post.

    I will be returning to your site for more soon.

  90. I like the helpful info you provide in your articles. I’ll bookmark your weblog and check again here frequently. I’m quite certain I’ll learn many new stuff right here! Best of luck for the next!

  91. MetroClick specializes in building completely interactive products like Photo Booth for rental or sale, Touch Screen Kiosks and Digital Signage, and experiences. With our own hardware production facility and in-house software development teams, we are able to achieve the highest level of customization and versatility for Photo Booths, Touch Screen Kiosks and Digital Signage. MetroClick, 121 Varick St, #301, New York, NY 10013, +1 646-843-0888

  92. Jada:

    Hi there it’s me, I am also visiting this web site regularly, this site is truly good and the visitors are genuinely sharing fastidious thoughts.

  93. Hi there! Do you use Twitter? I’d like to follow you if that would be
    ok. I’m undoubtedly enjoying your blog and
    look forward to new posts.

  94. This piece of writing presents clear idea in support of the new users of
    blogging, that genuinely how to do blogging.

  95. What’s up, this weekend is good designed for me, as this moment i
    am reading this impressive educational article here at my home.

  96. Great – I should certainly pronounce, impressed with your site. I had no trouble navigating through all the tabs and related information ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or anything, site theme . a tones way for your client to communicate. Nice task.

  97. I do believe all the ideas you have presented on your post. They’re very convincing and can certainly work. Nonetheless, the posts are too short for starters. May you please lengthen them a bit from next time? Thank you for the post.

  98. My brother recommended I might like this blog. He was entirely right. This post actually made my day. You cann’t imagine just how much time I had spent for this info! Thanks!

  99. Hello There. I found your blog using msn. This is a very well written article. I’ll be sure to bookmark it and return to read more of your useful info. Thanks for the post. I will certainly comeback.

  100. I’ve been absent for some time, but now I remember why I used to love this blog. Thank you, I’ll try and check back more often. How frequently you update your website?

  101. hello!,I like your writing so so much! share we communicate more approximately your post on AOL? I need an expert on this area to unravel my problem. May be that’s you! Looking ahead to look you.

  102. I am continuously invstigating online for ideas that can assist me. Thx!

  103. Great work! That is the kind of information that are supposed to be shared across the net. Disgrace on the seek engines for no longer positioning this put up higher! Come on over and discuss with my site . Thanks =)

  104. MetroClick specializes in building completely interactive products like Photo Booth for rental or sale, Touch Screen Kiosks and Digital Signage, and experiences. With our own hardware production facility and in-house software development teams, we are able to achieve the highest level of customization and versatility for Photo Booths, Touch Screen Kiosks and Digital Signage. MetroClick, 121 Varick St, #301, New York, NY 10013, +1 646-843-0888

  105. Hi there, just turned out to be receptive to your web page through Bing and yahoo, and realized that it’s truly useful. I will value if you maintain this post.

  106. I was very pleased to uncover this site. I need to to thank you for your time for this particularly fantastic read!! I definitely enjoyed every little bit of it and i also have you book marked to check out new information in your website.

  107. I merely hope to notify you that I am new to blogging and extremely enjoyed your post. More than likely I am likely to bookmark your blog post . You indeed have stunning article information. Acknowledge it for expressing with us your domain write-up

  108. Thank you for any other great post. Where else may anybody get that type of info in such a perfect manner of writing? I have a presentation subsequent week, and I am on the look for such information.

  109. I¡¦ve been exploring for a bit for any high-quality articles or blog posts in this sort of area . Exploring in Yahoo I eventually stumbled upon this website. Reading this information So i am glad to exhibit that I’ve a very just right uncanny feeling I came upon just what I needed. I such a lot indisputably will make certain to do not disregard this website and provides it a glance on a continuing basis.

  110. Faytech North America is a touch screen Manufacturer of both monitors and pcs. They specialize in the design, development, manufacturing and marketing of Capacitive touch screen, Resistive touch screen, Industrial touch screen, IP65 touch screen, touchscreen monitors and integrated touchscreen PCs. Contact them at http://www.faytech.us, 121 Varick Street,3rd Floor,New York, NY 10013,+1 646 205 3214

  111. It’s appropriate time to make some plans for the future and it’s time to be happy. I have read this post and if I could I desire to suggest you few interesting things or advice. Maybe you can write next articles referring to this article. I desire to read even more things about it!

  112. Emeryeps is a SEO(Search Engine optimzation) and Internet Marketing company. They help businesses to get traffic from various search engine and online community. They have seo experts and consultants with many years of SEO Experiences. No matter where your business is located, EmeryEPS.com can help your business to secure your highly convertible leads online.

Оставить коментарий