Источники ацетилхолина

Результаты наших исследований противоречат этой простой картине. Везикулы действительно запасают ацетилхолин и играют важную роль в его регуляции внутри клеток, но не они являются источником ацетилхолина, выделяющегося из нервных окончаний. Оказалось, что ацетилхолин высвобождается непосредственно из цитоплазмы, которой в основном заполнен нейрон. Механизм высвобождения управляется соединениями, скорее всего, белковой природы, которые погружены в мембрану нервной клетки. Такой белок может действовать как клапан, обеспечивая прохождение ацетилхолина сквозь мембрану.

Этот участок кругооборота ацетилхолина всегда устроен в общем одинаково и мало различается у разных животных или в разных тканях одного и того же животного. Более того, передача сигнала от холинергического нервного окончания, т.е. от нервного окончания, высвобождающего в качестве нейромедиатора ацетилхолин, не зависит от природы клетки, к которой подходит это окончание. Такой клеткой может быть мышечное волокно, секреторная клетка или другой нейрон. Окончания располагаются на концах аксонов (длинных отростков нервных клеток), так что нервные окончания называют иногда аксонными окончаниями. Совокупность нервного окончания, специализированного участка иннервируемой клетки в непосредственной близости от него и пространства между ними (синаптической щели)носит название синапса.

Высвобождение ацетилхолина вызывается электрическим импульсом, приходящим по аксону к нервному окончанию. В покоящемся нейроне между наружной и внутренней сторонами клеточной мембраны существует разность потенциалов величиной в несколько десятков милливольт.

 

 

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