Нарушение высших, кортикальных функций

Кажется довольно странным, что при болезни, примечательной нарушением высших, кортикальных функций, все известные нейрохимические изменения обнаруживаются в основном в субкортикальных нейронах.

В действительности, однако, при болезни Альцгеймера утрачивается и большое число кортикальных нейронов; показано также, что у некоторых больных падает уровень одного из минорных кортикальных медиаторов — соматостатина. Недавнее сообщение группы исследователей из Медицинского колледжа Университета шт. Айова позволяет полагать, что при болезни Альцгеймера могут поражаться и нейроны гиппокампа, передающие информацию к иным областям мозга. То, что пока не удается найти связь между гибелью этих нейронов и недостатком какого-нибудь определенного медиатора, может означать, что они выделяют или неизвестный медиатор, или такой же, как многие другие, непораженные нейроны и их отсутствие не снижает заметным образом его уровень в мозгу.

Что такое слон на ощупь?

Разные исследователи склонны были замечать — или по крайней мере рассматривать — лишь какую-то одну из шести различных групп признаков болезни Альцгеймера; соответственно они собрали шесть групп данных. После этого ученые, по крайней мере в интересах стратегии дальнейших исследований, сделали вывод, что причина болезни Альцгеймера кроется в чем-то одном — будь то генетическая аномалия, накопление белка, инфекция, токсин, нейрохимическое поражение или сосудистая недостаточность. Именно так вели себя шесть слепцов, решивших, что слон похож на разные предметы — стену, копье, змею, дерево, веер и канат — в зависимости от того, какую часть его тела каждому из них удалось ощупать. Слон действительно похож на все эти предметы, однако несчастные не смогли представить его целиком, так сказать, познать существо его «слоновости».

Не так давно те, кто изучал канцерогенез, опять же как минимум в стратегических целях, считали, что рак вызывается чем-то одним — вирусами, пищей, поврежденными генами, токсинами, радиоактивным облучением или дефектами в иммунной системе. Как оказалось, правы были все; и теперь они обратились к поискам того, что такое «слоновость»рака. Возможно, скоро так будет и с болезнью Альцгеймера.

 

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