Описание механизма высвобождения ацетилхолина

Как в рамках описанного механизма высвобождения ацетилхолина объяснить существование субминиатюрных и миниатюрных потенциалов концевой пластинки? Представим себе, что гипотетический белок, имеющий отношение к транспорту ацетилхолина, образует в мембране полимерный комплекс, или, иными словами, макромолекулу, состоящую из элементов, которые могут собираться вместе и диссоциировать. В покоящемся нейроне он находится в диссоциированном состоянии, а его элементы слишком малы, чтобы их можно было наблюдать в виде частиц при электронной микроскопии. Вход кальция в нервное окончание приводит к объединению элементов в полимерный комплекс, который какое-то время виден как крупная внутримембранная частица. Можно предположить, что этот процесс связан с высвобождением порции («кванта») молекул цитоплазматического ацетилхолина: частица действует как канал, специфический для ацетилхолина и открывающийся на короткое время, чтобы «выпустить» нужное его количество (скажем, «квант» из нескольких сотен молекул), достаточное для генерации субминиатюрного потенциала концевой пластинки. А синхронное образование определенного числа полимерных комплексов в данном участке синапса приведет к возникновению миниатюрного потенциала; аналогичный процесс во всей пре- синаптической мембране создаст полный нервный импульс.

 

 

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