Палочки- агрегаты прионов

 П. Мерц и Р. Саммер- вил из Нью-Йоркского государственного института фундаментальных исследований патологии развития обнаружили, что высокоочишенные препараты фактора, вызывающего скрэпи, содержат многочисленные палочковидные структуры, и предположили, что они-то и есть инфекционный агент. Прузинер считает палочки агрегатами прионов. Если палочки окрасить конго красным, они становятся очень похожи на амилоид, присутствующий в мозгу у овец, больных скрэпи, и у некоторых людей, страдающих болезнью Крейцфельдта—Якоба. Как полагает Прузинер, этот амилоид представляет собой именно скопления прионовых палочек. По его мнению, амилоид, обнаруживаемый при болезни Альцгеймера, — тоже скопления прионов, которые и могут быть ее возбудителем.

Д. Гайдушек из Национального института неврологических расстройств и инсульта и его коллеги наблюдали аномальные структуры, построенные из закрученных волокон, в мозгу животных, больных скрэпи, и людей, страдающих болезнью Крейцфельд- та—Якоба или куру. (Куру — это неврологическое расстройство, распространенное в некоторых племенах Новой Гвинеи. За доказательство заразности куру и болезни Крейцфельдта—Якоба Гайдушек был удостоен в 1976 г. Нобелевской премии.) Они предположили, что эти волокнистые образования и являются инфекционным агентом. Подобные структуры отсутствуют при болезни Альцгеймера, однако некоторые их иммунологические свойства совершенно такие же, как у нейрофибриллярных клубков.

Если болезнь Альцгеймера вызывается инфекционным агентом, она должна быть заразной; однако попытки передать ее лабораторным животным были безуспешными. Возможно, в данном случае для того чтобы произошло заражение болезнетворным агентом (если таковой имеется), необходимо определенное генетическое «обеспечение», сопутствующее иммунологическое расстройство или предварительное воздействие какого-то токсина из внешней среды.

 

 

66 Comments

  1. Bdsm:

    933141 885200Depending on yourself to make the decisions can truly be upsetting and frustrating. It takes years to build confidence. Frankly it takes much more than just happening to happen. 832349

  2. It’s very simple to find out any matter on web as compared to
    textbooks, as I found this paragraph at this website.

  3. Excellent blog you have got here.. It’s difficult to find high-quality
    writing like yours these days. I seriously appreciate people like you!

    Take care!!

  4. What’s up, after reading this amazing piece of writing i am too happy to share my knowledge here with friends.

  5. Hi colleagues, how is all, and what you want to say regarding this post, in my view its truly remarkable designed for me.

  6. Usually I do not read article on blogs, however I would like to say that this write-up very pressured
    me to check out and do so! Your writing style has been amazed me.
    Thanks, very nice article.

  7. You could certainly see your enthusiasm in the article you write.
    The sector hopes for more passionate writers like you who aren’t
    afraid to say how they believe. At all times follow your heart.

  8. Simply want to say your article is as surprising. The clarity in your post is just
    excellent and i can assume you’re an expert on this subject.
    Well with your permission allow me to grab your feed to keep up to date with forthcoming post.

    Thanks a million and please keep up the rewarding work.

  9. Thankfulness to my father who told me concerning this
    blog, this webpage is in fact remarkable.

  10. What’s up to every one, the contents existing at this web
    site are truly remarkable for people knowledge, well, keep up the good work
    fellows.

  11. I don’t even know how I ended up here, but I thought this post was good.
    I do not know who you are but definitely you’re going to a famous blogger if you aren’t already ;
    ) Cheers!

  12. Geri:

    of course like your web site however you need to test the spelling on quite a few of
    your posts. A number of them are rife with spelling
    problems and I find it very troublesome to tell the truth however I will certainly come again again.

  13. Hi there, I found your web site by means of Google while
    searching for a similar matter, your site got here up, it appears to be like great.
    I have bookmarked it in my google bookmarks.
    Hi there, simply become aware of your blog thru Google, and located that it’s
    truly informative. I’m gonna watch out for brussels.

    I’ll appreciate when you proceed this in future. Numerous folks will likely be benefited from your writing.
    Cheers!

  14. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
    You definitely know what youre talking about, why throw away your intelligence on just posting videos to your
    weblog when you could be giving us something enlightening to read?

  15. Excellent beat ! I would like to apprentice whilst you amend
    your site, how can i subscribe for a blog site? The account helped me a applicable deal.
    I had been tiny bit acquainted of this your broadcast provided vibrant clear idea

  16. Hello, its pleasant post on the topic of media
    print, we all know media is a fantastic source of information.

  17. I blog quite often and I genuinely thank you for your information.
    The article has truly peaked my interest. I am going to take a note
    of your website and keep checking for new details about once a week.

    I subscribed to your RSS feed too.

  18. When I initially commented I clicked the «Notify me when new comments are added» checkbox and
    now each time a comment is added I get several emails with the
    same comment. Is there any way you can remove me from
    that service? Thank you!

  19. When I originally left a comment I appear to have clicked on the -Notify me when new
    comments are added- checkbox and from now on every time a comment
    is added I recieve 4 emails with the exact same comment.

    Is there a means you are able to remove me from that service?
    Thanks a lot!

  20. Hi there! Do you use Twitter? I’d like to follow you if that would be ok.
    I’m undoubtedly enjoying your blog and look
    forward to new updates.

  21. Hey! Do you know if they make any plugins to assist with SEO?
    I’m trying to get my blog to rank for some targeted keywords
    but I’m not seeing very good success. If you know of any please share.
    Thanks!

  22. Hi this is kind of of off topic but I was wanting to know
    if blogs use WYSIWYG editors or if you have to manually code with
    HTML. I’m starting a blog soon but have no coding expertise
    so I wanted to get advice from someone with experience.
    Any help would be greatly appreciated!

  23. Write more, thats all I have to say. Literally,
    it seems as though you relied on the video to make your point.
    You clearly know what youre talking about, why waste your
    intelligence on just posting videos to your blog when you could be giving us something informative to read?

  24. It’s enormous that you are getting ideas from this article as well as from our
    argument made at this place.

  25. Hmm is anyone else having problems with the pictures on this blog loading?
    I’m trying to figure out if its a problem on my end or if it’s the blog.
    Any feed-back would be greatly appreciated.

  26. If you are going for most excellent contents like myself, simply pay a quick visit this web
    site daily because it offers quality contents, thanks

  27. Aw, this was a really nice post. Finding the time and actual effort to produce
    a great article… but what can I say… I put things off a lot and don’t seem to get anything done.

  28. I am curious to find out what blog platform you have been utilizing?
    I’m experiencing some minor security issues with my latest website and I would like to find something more
    safeguarded. Do you have any solutions?

  29. Your style is unique in comparison to other people I have read stuff from.
    Thanks for posting when you’ve got the opportunity, Guess I’ll
    just book mark this blog.

  30. Thanks for sharing your thoughts on electronic systems.

    Regards

  31. I every time spent my half an hour to read this website’s content daily
    along with a mug of coffee.

  32. We stumbled over here different web address and thought I might check things out.

    I like what I see so i am just following you.
    Look forward to exploring your web page again.

  33. I couldn’t refrain from commenting. Exceptionally well written!

  34. I read this article completely about the resemblance of most recent and earlier technologies, it’s remarkable article.

  35. Quality content is the important to invite the viewers to pay
    a visit the website, that’s what this website is providing.

  36. Hello! Do you use Twitter? I’d like to follow you if that would be okay.
    I’m definitely enjoying your blog and look forward to new updates.

  37. If you wish for to improve your knowledge simply keep visiting this website and be updated with the latest news update posted here.

  38. Hi there i am kavin, its my first occasion to commenting anyplace, when i
    read this post i thought i could also make comment due to this good article.

  39. Just want to say your article is as astonishing.
    The clearness to your post is just nice and that i can think you’re knowledgeable in this subject.
    Well with your permission let me to clutch your RSS feed to stay updated with
    imminent post. Thanks a million and please carry on the enjoyable work.

  40. As the admin of this web page is working,
    no hesitation very soon it will be famous, due to its quality contents.

  41. Hi there, I log on to your blogs regularly. Your story-telling style is awesome, keep doing what you’re doing!

  42. I just want to tell you that I am newbie to blogging and honestly enjoyed your web blog. Most likely I’m going to bookmark your site . You actually have terrific writings. Thanks a bunch for sharing with us your web page.

  43. When someone writes an post he/she keeps the plan of a user in his/her brain that how a user can know
    it. So that’s why this article is great. Thanks!

  44. I have learn some good stuff here. Certainly price bookmarking for revisiting.
    I surprise how a lot attempt you set to
    create the sort of fantastic informative website.

  45. I appreciate, result in I discovered exactly what I used
    to be taking a look for. You have ended my 4 day long hunt!
    God Bless you man. Have a great day. Bye

  46. You are so cool! I do not believe I’ve read something like this before.
    So great to find someone with some original thoughts on this issue.
    Seriously.. thank you for starting this up. This web site is one thing that’s needed
    on the web, someone with a little originality!

  47. Someone essentially help to make seriously posts I might state.
    This is the first time I frequented your website page and to this point?
    I amazed with the analysis you made to make this particular put up amazing.
    Fantastic task!

  48. Hello, I enjoy reading all of your article post.
    I like to write a little comment to support you.

  49. Hey are using WordPress for your site platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you need any coding knowledge to make your own blog? Any help would be greatly appreciated!

  50. Hello to every one, because I am really eager of reading this web site’s post to be updated daily.
    It contains good stuff.

  51. Very good post. I’m dealing with many of these issues as well..

  52. Superb blog you have here but I was curious about if you knew of any discussion boards that cover the same topics talked about here? I’d really love to be a part of group where I can get feed-back from other knowledgeable individuals that share the same interest. If you have any recommendations, please let me know. Thanks a lot!

  53. Thanks for the sensible critique. Me & my neighbor were just preparing to do some research on this. We got a grab a book from our area library but I think I learned more from this post. I am very glad to see such magnificent information being shared freely out there.

  54. It’s awesome to pay a visit this web site and reading the views of
    all colleagues about this piece of writing, while I am also zealous of getting
    experience.

  55. Anke:

    Hi there superb website! Does running a blog such as this require a large amount of work?
    I’ve virtually no understanding of computer programming however I was
    hoping to start my own blog soon. Anyhow, if you have any suggestions or techniques for new blog owners please share.

    I know this is off topic however I simply needed to ask.

    Thanks a lot!

  56. Pretty section of content. I just stumbled upon your weblog and in accession capital to assert
    that I get in fact enjoyed account your blog posts.

    Anyway I’ll be subscribing to your feeds and even I achievement you
    access consistently quickly.

  57. Hi there to all, since I am truly keen of reading this weblog’s post to be updated regularly.
    It contains good information.

  58. Write more, thats all I have to say. Literally, it seems as though you relied
    on the video to make your point. You obviously know what youre talking about, why throw away your intelligence
    on just posting videos to your weblog when you could
    be giving us something informative to read?

  59. Hello, i think that i saw you visited my blog so i came to “return the favor”.I am attempting to find things to improve my web site!I suppose its ok to use a few of your ideas!!

  60. We’re a group of volunteers and starting a new scheme in our community.
    Your website provided us with useful information to work
    on. You have performed an impressive process and our whole neighborhood will probably
    be grateful to you.

  61. Hello, Neat post. There is an issue together with your site in internet explorer, may check this… IE still is the market leader and a big component to other people will leave out your magnificent writing due to this problem.

  62. Valuable info. Lucky me I discovered your site by chance, and I’m shocked why this coincidence didn’t took place in advance! I bookmarked it.

  63. You have brought up a very wonderful points , appreciate it for the post.

  64. I have been surfing online more than 3 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. Personally, if all site owners and bloggers made good content as you did, the web will be a lot more useful than ever before.

Оставить коментарий