Пузырек с лекарством

ЧТОБЫ лечить нарушения обмена веществ, неоднократно пытались использовать синтетические пептидные препараты, однако на этом пути неизбежно вставало обескураживающее препятствие: ферменты организма быстро расщепляют молекулы лекарства на составляющие его аминокислоты, так что время жизни однократно введенного препарата очень невелико, часто менее часа, а значит, и лечебный эффект его ограничен. Проблема была бы решена, если бы удалось придумать способ, обеспечивающий постепенное появление лекарственных пептидных молекул в организме. В последнее время произошли события, которые возродили интерес к объектам, уже давно привлекавшим внимание в этом отношении. Речь идет о липосомах — так называют миниатюрные сферические пузырьки из липидных пленок, которые можно считать искусственным аналогом мембран живой клетки (липиды — их основной компонент).

Первые липосомы были получены более двадцати лет назад в лаборатории А.Бэнгхема (Институт физиологии животных при Совете научных исследований в области сельского хозяйства в Кембридже, Великобритания). Бэнгхем и его сотрудники открыли, что некоторые липиды, если их диспергировать в воде, склонны образовывать замкнутые пузырьки. Большей частью такие структуры представляют собой несколько концентрических двойных слоев из молекул липида. Впоследствии было обнаружено, что, если раствор, содержащий липосомы, подвергнуть воздействию ультразвука, пузырьки становятся меньше и однороднее по размеру. Довольно скоро выяснилось, что лекарственные препараты или какие-либо другие биологически активные вещества можно помещать внутрь липосомы, включая в состав либо липидных бислоев, либо раствора, заполняющего пространство между ними. Разработка этого метода тормозилась тем, что не было достаточно экономичного способа получать липосомы одновременно и стабильные и эффективные как «ловушки» для соответствующих веществ. И долгое время считалось, что липосомы представляют интерес лишь в экспериментальной научной работе, главным образом в качестве моделей биологических мембран.

 

 

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