Самый нервный пучок

В обоих случаях это был пучок MP/dMP2 — тот самый нервный пучок, который (как говорилось выше) распознавался конусом роста рСС, но не аСС. Другими словами, удалось показать, что среди нервных пучков, доступных для конкретного конуса роста, есть один, отличный от всех остальных по своим антигенным детерминантам. Все что говорилось до сих пор, рисует довольно статичную картину развития. В действительности же в нем все изменчиво и взаимосвязано. Например, мы описали, как на определенной стадии эмбриогенеза конус роста нейрона G и его филоподии проявляют специфическое сродство к двум аксонам Р. Но через некоторое время аксон С образует три новых конуса роста. Два из них, вытягиваясь, становятся билатерально симметричными дендритами, а третий дает начало вторичному аксону, и все эти вновь образованные отростки идут в различные нервные пучки, к которым первоначальный конус роста сродства не имел. Ясно, что сродство конусов роста отдельного нейрона к клеточным поверхностям должно меняться со временем. Можно думать, что это происходит как в результате реализации некоторой внутренней программы данного нейрона, так и вследствие его взаимодействия с другими нервными клетками. Мы думаем, например, что последовательные изменения в свойствах поверхности того или иного конуса роста делают возможным его переход от одного нервного пучка к другому по направлению к конечной цели. Но каким образом биохимический аппарат клетки «знает», где в данный момент находится ее конус роста и с чем он взаимодействует? Возможно, дело в избирательном включении материала филоподий в другие нервные клетки. Такое межклеточное взаимодействие мы обнаружили, анализируя электронные микрофотографии в поисках участков контакта между филоподнями и клеточными поверхностями. Мы уже говорили об избирательной адгезии филоподий нейрона С с поверхностью аксонов и филоподий нейронов Р. Интересно, что происходит и обратное: филоподии нейронов Р имеют контакты с конусом роста нейрона С, причем материал филоподий может включаться в состав конуса роста (при этом образуются окаймленные поры и везикулы — специальные клеточные структуры, с помошью которых обычно осуществляется транспорт крупных молекул внутрь клетки). Процесс включения высокоспецифичен.

 

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