Токсин соли алюминия

Некоторые исследователи находят основания полагать, что соли алюминия способствуют развитию болезни Альцгеймера. Эти соли присутствуют в питьевой воде, могут содержаться в пище и лекарствах (их добавляют, например, в некоторые плавленые сыры, в антацидные препараты, которыми пользуются при повышенной кислотности желудка, в определенные виды таблеток аспирина), а также попадать в них со стенок алюминиевых резервуаров и посуды. Д. Перл из Медицинского колледжа Вермонтского университета обнаружил, что алюминий накапливается преимущественно в нейронах, содержащих нейрофибриллярные клубки. И. Клацо и Г. Вишиевски (тогда они работали в Национальном институте неврологических расстройств и инсульта) сообщили, что у кроликов и кошек (но не у мышей, крыс или обезьян) введение солей алюминия приводит к образованию в мозгу нейрофибриллярных клубков. Как показал Д. Маклоглин (медицинский факультет Торонтского университета), этот эффект проявляется, когда концентрация алюминия в мозгу достигает того же уровня, что и при болезни Альцгеймера.

По мнению А. Элфри из Медицинской школы Колорадского университета, необратимое слабоумие, нередко наблюдаемое у людей, которые неоднократно подвергались гемодиализу с

использованием богатых алюминием растворов, связано с повышением содержания алюминия в мозгу. Известно, что некоторые ферменты мозга ингибируются алюминием и что соли алюминия способны нарушать транспорт ряда белков (в том числе предшественников нейрофиламентов) из тела нейрона по аксону к нервным окончаниям. Гайдушек обнаружил, что на острове Гуам у населения некоторых общин высокий уровень алюминия в мозгу сопутствует слабоумию; по- видимому, из-за недостатка кальция в местной питьевой воде организм поглощает больше алюминия.

Однако все эти указания на участие алюминия в патологическом процессе можно подвергнуть сомнению. Ассоциация алюминия с нейрофибриллярными клубками может означать только то, что уже сформировавшиеся клубки имеют сродство к алюминию. Те нейрофибриллярные клубки, которые индуцируются алюминием у кроликов и кошек, состоят из однонитчатых, а не парных спиральных филамсн- тов и образуются они в частях нервной системы, которые не поражаются при болезни Альцгеймера. Некоторые симптомы и характерные черты слабоумия, связанного с гемодиализом, не наблюдаются при болезни Альцгеймера. Вполне возможно, что алюминий сам по себе не вызывает характерные для нее симптомы, однако его присутствие способствует их появлению у людей, подвергшихся воздействию

иного фактора, служащего первопричиной заболевания.




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