Высокоэффективные липосомы

И все же метод липосом не сходил со сцены, исследования различных его аспектов продолжались. В 1981 г. возникло коммерческое предприятие Liposome Company, Inc., целью которого было использовать на практике все, что известно о липосомах. Прежде всего сотрудники этой фирмы занялись тремя ключевыми проблемами — поисками возможностей удешевить производство липосом,добиться их стабильности и максимальной эффективности как «ловушек» для различных соединений. Два года назад исследователи, работавшие в одной из лабораторий компании в Принстоне, сообщили, что им удалось разработать дешевую методику получения стабильных и высокоэффективных липосом.

За прошедшее с тех пор время было показано, что получаемые этим методом липосомы (исходным материалом для них служит преимущественно лецитин яичного желтка) отлично подходят для длительного постепенного вы

свобождения лекарственного препарата внутри организма. Если такие липосомы нагрузить лекарством и ввести в мышцы, содержимое «вытекает» из них довольно долго (вплоть до 20 дней) вследствие постепенного разрушения липидных слоев (вероятно, под действием ферментов организма; липиды, видимо, включаются в метаболизм).

В конце 1983 г. Liposome Company объявила, что она заключила долгосрочное соглашение на несколько миллионов долларов с властями Валлонской области Бельгии, с одной из бельгийских фирм и с Католическим университетом в Лувене. Их цель — объединить усилия и создать надежную липосомную систему с препаратами против малярии, а также заболеваний печени, в частности гепатита и гепатом. Участие бельгийских ученых в этом проекте очень ценно, так как ими разработаны методики получения «прицельных» лекарственных препаратов.

Реактивное плавание кальмаров

Плывущий кальмар всасывает и выбрасывает воду, сокращая мышцы стенки своей мантии. Эластичные коллагеновые «пружины» в мышцах увеличивают мощность реактивного толчка

Среди животных, которые бегают, плавают или летают, быстрее всех это получается у позвоночных и насекомых. Их двигательные способности обусловлены жестким скелетом, построенным из прочного материала — костей или кутикулы, которые служат опорой мышцам.

 

 

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